3001300
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MYC (8q24) Gene Rearrangement by FISH

MYC FISH
Example Reports
Negative
Positive

Ordering Recommendation

Facilitates diagnosis of Burkitts lymphoma (BL) and B-cell lymphoma with features intermediate between BL and diffuse large B-cell lymphoma (DLBCL). Detects all MYC rearrangements, including t(8;14), t(2;8), and t(8;22).

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation
Collect

Tumor tissue.

Specimen Preparation

Formalin fix (10 percent neutral buffered formalin) and paraffin-embed specimen. Protect paraffin block from excessive heat. Transport tissue block or 5 unstained (3-micron thick sections) positively charged slides in a tissue transport kit (ARUP supply #47808) available online through eSupply using ARUP Connect ™ or contact ARUP Client Services at (800) 522-2787 (kit is recommended but not necessary). (Min: 2 slides)

Storage/Transport Temperature

Room temperature or refrigerated. Ship in cooled container during summer months.

Unacceptable Conditions

Paraffin block with no tumor tissue remaining. Specimens fixed in any fixative other than 10 percent neutral buffered formalin. Decalcified specimens.

Remarks

Include surgical pathology report.
If multiple specimens (blocks or slides) are sent to ARUP, they must be accompanied by one of the following: an order comment indicating that the ARUP pathologist should choose the specimen most appropriate for testing (e.g., "Choose best block"), or individual orders for each sample submitted. A Pathologist Block Selection Fee (ARUP test code 3002076) will be added to orders that utilize the first option. If multiple specimens are sent to ARUP without a request for pathologist block/slide selection or individual orders, they will be held until clarification is provided.

Stability

Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable

Methodology

Fluorescence in situ Hybridization (FISH)

Performed

Mon-Fri

Reported

3-7 days

Reference Interval

By report

Interpretive Data

Refer to report.  

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Compliance Category

Analyte Specific Reagent (ASR)

Note

Hotline History

N/A

CPT Codes

88366

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Components

Component Test Code* Component Chart Name LOINC
3000616 MYC FISH Reference Number
3000617 MYC FISH Source
3000618 MYC FISH Result
3000703 Scoring Method 81304-8
3002948 Total Cell Count 78236-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • 8q24 gene rearrangement FISH
  • Burkitt's Lymphoma
  • MYC FISH
  • MYC gene rearrangement FISH
MYC (8q24) Gene Rearrangement by FISH